About VetriScience
VetriScience, a brand of FoodScience, LLC, has been developing veterinarian-formulated pet supplements for nearly four decades out of its Williston, Vermont headquarters. The company's foundational product, GlycoFlex, launched in 1981 as the first commercially available glucosamine supplement for dogs, and VetriScience has since built out a full line covering calming and cognition, hip and joint mobility, dental, digestive, and multivitamin support for both dogs and cats. In 2014 it added a Pro Line developed specifically for veterinary-clinic use, and the company says its supplements are now used in more than 15,000 veterinary clinics in the U.S.
Every VetriScience formula is manufactured in an SQF-certified U.S. facility, with routine third-party testing and label transparency the company points to as a differentiator in a supplement category not always known for either. Its calming line, including the Calm & Confident chews we feature here, is built around L-theanine, an amino acid with feline-specific published research behind it, rather than the melatonin- or botanical-heavy formulas common elsewhere in the category.
Brand website: vetriscience.com
What VetriScience makes
VetriScience's range runs wider than the products we review. The lines we know best from our own testing are marked with a star:
Calming & Cognition
L-theanine-based calming chews, including Calm & Confident — the line our featured pick belongs to — featured on House of Mittens
Hip, Joint & Mobility
joint-support formulas descended from VetriScience's original 1981 GlycoFlex glucosamine line
Dental
dental-care chews and formulas for cats
Probiotic & Digestion
digestive-support supplements for cats
Multivitamin
daily multivitamin support formulas for cats
Skin, Coat & Allergy
skin and coat health formulas for cats
Why we recognized VetriScience
The House of Mittens Top Brand recognition isn't paid for and can't be applied for. We award it to the brands whose products consistently stand out in our vet-reviewed category guides. VetriScience earned it on the strength of the products below, evaluated the same way every product on this site is: assessed against feline-health criteria, used with real cats, and judged on merit.
VetriScience products we rated highly
VetriScience Calm & Confident Chews for Cats, Chicken, 30 Count
Built on L-theanine, the one calming ingredient in this category with feline-specific published research behind it rather than research borrowed from dogs or extrapolated from human supplements. The formula is deliberately non-sedating, with no melatonin and no antihistamine, so a treated cat stays awake and responsive rather than groggy, which matters if you're watching for nausea on a car ride. It's the calming chew we see recommended in more veterinary practices than any other in the category, and it carries over 12,000 Amazon ratings, the deepest review base among the calming treats in our roundup.
Read the 10 Best Cat Calming Treats of 2026, Vet-Reviewed guide →What earned VetriScience the recognition
- Built on L-theanine, the calming ingredient in this category with the strongest feline-specific published research behind it, rather than research borrowed from dogs or extrapolated from human use.
- A non-sedating formula, with no melatonin and no antihistamine, so a treated cat stays alert and responsive instead of groggy.
- Backed by over 12,000 Amazon ratings, the deepest review base among the calming treats we evaluated.
- Manufactured in an SQF-certified U.S. facility with routine third-party testing and full label transparency, and used in more than 15,000 veterinary clinics.
- Nearly four decades in the animal-health industry, tracing back to VetriScience's 1981 launch of GlycoFlex, the first commercially available glucosamine supplement for dogs.